Decoupling of Tumor-Initiating Activity from Stable Immunophenotype in HoxA9-Meis1-Driven AML
نویسندگان
چکیده
منابع مشابه
Decoupling of tumor-initiating activity from stable immunophenotype in HoxA9-Meis1-driven AML.
Increasing evidence suggests tumors are maintained by cancer stem cells; however, their nature remains controversial. In a HoxA9-Meis1 (H9M) model of acute myeloid leukemia (AML), we found that tumor-initiating activity existed in three, immunophenotypically distinct compartments, corresponding to disparate lineages on the normal hematopoietic hierarchy--stem/progenitor cells (Lin(-)kit(+)) and...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2012
ISSN: 1934-5909
DOI: 10.1016/j.stem.2012.02.019